EPH155 Analysis of the Risk Factors for Failed Back Surgery Syndrome: Real-World Evidence

Failed back surgery syndrome (FBSS) is defined as persistent pain following spine surgery, particularly when the procedure fails to relieve pre-operative symptoms. To understand FBSS prevalence, we identified patient characteristics which may predict development. De-identified records were extracted from Cerner Real World Data, a US electronic health record database. Patients who underwent between 2018-2019, and then those developed FBSS, via ICD-10 codes. The first was used index. Diagnoses of depression or anxiety assessed up six months pre-index using ICD-10-CM, while age, body mass index (BMI), sex evaluated at Number lifetime surgeries prior also evaluated. Univariate bivariate analyses conducted logistic regression report prevalence ratios (PR). A total 22,020 patients whom 728 (median age 61 years; 55% female). Compared aged 18-44, more likely in groups 45-54 55-64 by factors 1.38 (p=0.023) 1.33 (p=0.03), respectively. Those with history moderate 1.50x (p=0.04) have compared no history, overweight obese 1.48x (p=0.017) 1.92x (p<0.00001) normal BMIs. Prior linked higher prevalence: 2 (PR: 1.22, p=0.025), 3 1.43, p=0.0048), 4 1.88, p<0.00001), 5+ 2.36, p<0.00001). Bivariate found that females overweight, obese, moderately depressed, 1.66 (p=0.0271), 2.25 (p=0.00006), 1.81 (p=0.011), multitude contribute onset, highlighting need weigh benefits against risks considering surgical treatment for relief.